Global, Radical, Inspirational: The 13th Innovation Summit at the Royal Society of Medicine

Back in April I reported on my first RSM Medical Innovations event, which left me energised and considering a membership. In a similar but less impressive fashion to Victor Kiam, I also invested in the company, and so when I attended the 13th Innovation event, I was doing so as a fully paid up fellow of the society.

Not that this was a requirement of attending. Tickets were available for free, although it was understandably over-subscribed. One of the most refreshing features of the RSM innovation event is the diversity of the audience. We had students from a local secondary school, entrepreneurs, scientists, doctors, patients and the ever present wise heads of academia and retired clinicians.

Great audience for a great day @roysocmed #medinnov #theta360 – Spherical Image – RICOH THETA

Calmly and capably hosted by President of the RSM, Mr Babulal Sethia, the day was broken into 4 sections, and covered a wide range of medical innovations with speakers from across the world. Some focused on the problems of the developing world which took them ahead of their western peers and colleagues. Others looked to the non-medical disciplines to take a new angle on clinical challenges. There was even disruption of the standard research model, bearing fruit in areas such as regenerative medicine.

We started at the end, with an engrossing presentation from Dallas Pounds, Chief Executive of Royal Trinity Hospice ( www.royaltrinityhospice.london,@trinityhospice ). Currently undergoing a remarkable transformation of it’s own, the ground-breaking team are working hard to take information, support and advice about death and dying ‘on to the high street’, and are blurring the boundaries to allow people in to see their work first hand. We were given a preview of “OddsAndEnds” – a platform which allows people to explore and understand death and dying themselves, which launches in 2017

 


I’ve spoken about Mr Shafi Ahmed before, reporting on his ground-breaking live broadcast of an operation earlier this year (#VRinOR). He continues to blaze a trail in Virtual Reality education, and today he spoke passionately about the challenges facing the estimated 5 billion people across the globe that lack access to safe surgery. By delivering immersive high quality surgical training using Medical Realities ‘The Virtual Surgeon’ platform, it’s now possible to livestream operations to anywhere with a network connection. Thanks to Facebook and Google, that’s anywhere on the globe. Give it a few years, and Elon Musk will be delivering this to Mars.

It’s #medinnov day and I’ve struck gold already! Doyenne of surgical #VR @ShafiAhmed5 in the house! @roysocmed #innovation #digitalhealth #theta360 – Spherical Image – RICOH THETA

With NooraHealth (@noorahealth), the needs of the developing world also helped drive innovation. CEO Edith Elliott and MD candidate Shahed Alam, students arising from the design school methodology of Stanford, visited India and made brilliant use of the abundant resource of family to put in place an education and training programme that turned family into competent carers, with subsequent significant improvement in post-discharge outcomes. What’s really telling here is that this process would work wonders in the NHS and perhaps other ‘developed’ healthcare systems, as well as helping to improve quality and meet rising demand.

The work of Professor Helen Lee in developing a robust, simple, ‘nespresso’ style point of care test for bloodbourne viruses that would work in the heat and noise of Ghana was next. Innovation faces challenges from all sides, and the simple reality of operation and supply chain in Africa can get in the way of even the most elegant of solutions. By concentrating on the challenges faced by front-line workers, ‘Diagnostics for the Real World‘ have produced an award winning solution that can transform the diagnosis of these illnesses.

Professor Helen Lee and her 'Nespresso' PoCT machine
Professor Helen Lee and her ‘Nespresso’ PoCT machine

Alongside the growing problem of HIV, Iron Deficiency Anaemia affects 3.5 BILLION people across the globe. Yes, that’s a “B”. The associated health and developmental issues can significantly shorten lifespan and affect quality of life and economic output. Yet solving this problem, by providing suitable iron supplementation, has challenged even the brightest minds. Enter Dr Gavin Armstrong with the cute ‘Lucky Iron Fish’ (@luckyironfish). By providing a small iron fish which can be boiled for 10 minutes with their food, people can significantly supplement their iron intake without affecting flavour or causing significant side effects.

Design features of a Lucky Iron Fish
Design features of a Lucky Iron Fish

Once again, the idea and science might be smart, but the allied entrepreneurship, social marketing, cultural understanding and even the ‘buy 1 give 1’ plan have gone a long way to making this venture a success. Gavin was equally honest in sharing the important role of failure in learning and growing. In many ways I was put in mind of the work Lauren Braun and Alma Sana, who were one of my highlights of the previous RSM event I attended. You’ll appreciate why I immediately connected the two on twitter!


Innovation needn’t spring from within healthcare to work – in fact, looking outside traditional silos is a brilliant way of approaching problems in a novel way. For example, 3D printing technology has already found a place in traditional design and manufacture, but is increasingly being used by enterprising clinicians and scientists in surgery, training, and device manufacture. Had you ever thought about using it to produce a model of a diseased prostate to allow for surgical planning and patient education though? Thought not.

Hugo Lynch, founder of MPrint3D,  and Mr Richard Hindley, Conslutant Urological Surgeon from the Hampshire Hospitals NHS Trust, have moved from the already-awesome ‘fusion’ of high resolution MRI and ultrasound (which allows for extremely accurate transperineal prostate biopsy) to having the data converted to a solid object that can be handled by surgeon and patient alike. Yes – this means a 3d printed prostate. And yes – in what must be a world-first I got a selfie with it.

Dr Keith Grimes & 3D Printed Prostate (I'm on the left)
Dr Keith Grimes & 3D Printed Prostate (I’m on the left)

What’s immediately apparent is the incredible ability of a physical object to quickly and easily allow comprehension of what is often impenetrable information for both doctor and patient. Whether 3D printing is the best solution, or whether Virtual and Augmented Reality might perform as well, we shall see.

This is a question that is being answered by 3D4Medical (@3d4medical). Their iPad Anatomy series of apps have already revolutionised what is possible with tablet based anatomy teaching, a fact not lost on Apple themselves who invited them to help launch the iPad pro 2 years ago. It’s an amazing, intuitive and interactive piece of software, something I wish I’d had as a medical student back in the 1990’s. Dr Alan Detton & Niall Johnson took us through the latest version of the app, and offered a tantalising glimpse at ‘Project Esper’, their next step into Augmented Reality.

It was great to see Mindmate (www.mindmate-app.com @MindMateApp) making an appearance as well. Developed with the support of the Digital Health & Care Institute of Scotland (@DHIScotland), Patrick Renner took us through a slick presentation highlighting the features of this app, which provides assistance for people living with Dementia. We were joined by co-founder Susanne Mitschke (@susanneMitschke) via the app itself. By working closely with patients, families, and their care providers, the founders have used their experience in business, economics, and social sciences to accelerate the growth and adoption of this platform, which now has 12’000 monthly users.

 


Whilst the RSM, with its 182 year history, might be built on solid academic and research foundations, but it’s not shy of showcasing radical changes to this model.

iCancer is a crowdfunding campaign that famously raised £2million in just eight months to fund an oncolytc virus into Phase 1/2a trials. Liz Scarff, Alexander Masters, and Dominic Nutt, all personally touched by the effects of Neuroendrocrine tumours, brought together crowdsourced funds to directly revive a quiescent research corner into a rare disease. They then combined with a rich donor utilising ‘the Plutocratic Principle’ – where one wealthy individual can meet the majority of the cost of a trial and not only personally benefit, by entering that trial t hemselves (or allowing a friend/family member to do so) but also allow for many more people to benefit from the work. Strict ethical guidance is brought to bear, but with the generosity of donors forgotten research can be brought back to life, with the potential of developing novel treatments for all to share.

Ever heard of Bioelectronics? No, neither had I, until today. Dr Kris Famm, President of Galvani Bioelectronics, and Dr Nishan Ramnarain, Consultant in Pharmaceutical Medicine and Experimental Medicine Director at GlaxoSmithKline (@gsk), took us through some background on the use of precision modulation of nerve signals to control organ response and, thereby, whole system disease. For example, manipulation of the sympathetic nervous system at the carotid body can, in turn, help regulate blood sugar and blood pressure. Control of the sympathetic nervous system has long been known to play a crucial part in many illnesses, and treatment. When I was a junior doctor, I recall my surgical registrar opting for a highly selective vagotomy for his stomach ulcer over taking omeprazole. A whole class of medication is used to achieve the same effects. Having a new method of

Potential targets for Bioelectronics
Potential targets for Bioelectronics

Finally, we had two extremes to highlight the value of digital research tools:

At one end – Osman Kibar from Samumed (@Samumed_LLC). A serial entreprenuer and innovator, he presented some of the first findings of research into the existing corpus of knowledge on the Wnt signalling pathway. Through careful search methods, his company claims to have found a unique group of compounds that can modulate this biochemical pathway. This, in turn, has applications in regenerative medicine, degenerative disease and cancer. Showing evidence of paralysed mice walking again is strong stuff, and elicited an excited and slightly sceptical response from the audience.

At the other end, we had Renuka Chintapalli. Still at secondary school, she published her first paper aged 15, looking at the anti-cancer properties of common garlic. As if this wasn’t humbling enough, she has gone on to identify a novel bio-marker for oesophageal cancer by searching existing databases.


It’s always difficult to pick a highlight at an event like this, but my personal favorite had to be the presentation by Dr Liberty Foreman and Dr Katie Oliver, co-founders of Beamline Diagnostics (@beamlined).  The technology is impressive in its own right, using computational statistics to analyse data from infrared spectroscopy to detect the ‘chemical signature’ of early cancer changes. This has the scope to massively reduce the number of pathological samples that need formal scrutiny by allowing an accurate method of rapidly screening biopsy samples for cancerous changes. They’ve turned this into a product that can be operated at point-of-care too.

How did we do it? We just did it!
How did we do it? We just did it!

We have innovation in software, resurrection of a little used hardware modality, and a rapid practical impact on patient care in one. All of this would generally be enough to mark them out from the crowd, but what pushed them over the top was the refreshing honesty from the founders in how they formed their company – they just did it. Now faced with the tidal wave of new challenges, they push on regardless and deservedly look to make a success of their brave decision.

It’s the #JFDI* principle that is my personal mantra, and it’s a common thread in the innovations that tend to make the biggest impact. Is this because it indicates a personal characteristic in the inventor or founder of these projects? Does it mark the necessary bravery and energy required to break through the traditional barriers and inertia to change? Or is it just the troublemaker tendency in everyone that embarks on their quest to change things for the better? Whatever the answer, it makes events such as these endless entertaining, optimistic, and inspiring.

Finally, it was left to Dr Cristina de Juan (@cristina_djsj) from InnovateMedTec.com to wrap up, with a call for collaboration and connection across the globe to accelerate innovation. You can all take part, online, or in person, by attending the next event. Mark Saturday 22nd April, 2017 in your diary – I’ll see you there.

LINKS

DECLARATION OF INTERESTS

I am a fellow of the Royal Society of Medicine, mainly because I was so impressed by the venue and quality of the meetings when I came to the last event. I cover the membeship costs personally. The event was free to attend for all, and I paid all travel and food expenses, apart from the coffee served at the intervals!

Of course, I also wore my #PinkSocks – see previous post about the provenance of these fine items.

#PinksSocks #JFDI #Innovation
#PinksSocks #JFDI #Innovation

*#JFDI – Just F**king Do It

 

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